منابع مشابه
Systems biology of coagulation
Accurate computer simulation of blood function can inform drug target selection, patient-specific dosing, clinical trial design, biomedical device design, as well as the scoring of patient-specific disease risk and severity. These large-scale simulations rely on hundreds of independently measured physical parameters and kinetic rate constants. However, the models can be validated against large-...
متن کاملSystems Biology of Blood Coagulation and Platelet Activation
Blood clotting is a highly conserved physiological response that prevents excessive blood loss following vessel injury. It involves a sequence of plasma reactions leading to the formation of thromin (the coagulation cascade) as well as tightly controlled intracellular reactions mediating platelet activation. These two events are inextricably coupled, with the active platelet surface serving as ...
متن کاملMicrofluidics and coagulation biology.
The study of blood ex vivo can occur in closed or open systems, with or without flow. Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate analysis of platelet function, coagulation biology, cellular biorheology, adhesion dynamics, and pharmacology and, as a result, can be an invaluable tool for clinical diagnostics. An experimental session can acc...
متن کاملSystems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood
Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF), human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa) will generate thrombin after an initiation time (T(i)) of 1 to 2 hours (depending on donor), while activation of platelets with the GPVI-activator convulxin r...
متن کاملSystems biology and the biology of systems.
When I sit down to write an editorial for Physiology, I flatter myself that the two or three people who will ultimately read it want to hear my thoughts on a “big” topic. It strikes me that, within the rarefied realm of academic biology, there few bigger topics, or at least few topics more all encompassing in their scope, than Systems Biology. Perhaps it is the ambiguity inherent in its name th...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2013
ISSN: 1538-7933
DOI: 10.1111/jth.12220